Scientists are analyzing different drugs that are being used around the world for Covid-19 and taking stock of which all drugs could be effective against the virus.
Researchers catalogued every use documented in medical literature so far and found physicians have reported on the use of more than 100 different off-label and experimental treatments. The effort, called COvid19 Registry of Off-label & New Agents (CORONA), is an attempt to take an inventory of what’s being used where, as well as to spot any evidence of treatments that warrant further investigation in a randomized clinical trial. The findings published in Infectious Diseases and Therapy today.
The team reviewed about 2,700 published papers from all over the world detailing the treatment of COVID-19. From there, they gathered data on 9,152 patients and found doctors had tried 115 different drugs. These treatments were grouped into categories – antivirals were unsurprisingly the most common, followed by antibacterials and corticosteroids. The analysis also showed the use of immunosuppressants and blood substitutes, among other treatment options. Sheila Pierson, MS, the associate director for clinical research at the CSTL, director of registry enrollment for the CDCN, and the study’s senior author, led the analysis of the data.
“Our team has spent the last several years studying drugs used to control the cytokine storm in Castleman disease, so I’m glad we were able to apply these principles to COVID19. The work remains ongoing, and we are updating this drug inventory daily as we continue to compile information on other treatments as they’re being reported in the medical literature,” Pierson said.
Researchers note that the goal of this work is not to point toward the most effective treatment, but to provide a resource for what may be candidates for further study.